Stabilizing IκBα by “Consensus” Design
نویسندگان
چکیده
منابع مشابه
Stabilizing IκBα by “Consensus” Design
0022-2836/$ see front matter © 2006 E IκBα is the major regulator of transcription factor NF-κB function. The ankyrin repeat region of IκBα mediates specific interactions with NF-κB dimers, but ankyrin repeats 1, 5 and 6 display a highly dynamic character when not in complex with NF-κB. Using chemical denaturation, we show here that IκBα displays two folding transitions: a non-cooperative conve...
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Consensus problems occur in many contexts and have therefore been extensively studied in the past. In the original consensus problem, every process initially proposes a value, and the goal is to decide on a single value from all those proposed. We are studying a slight variant of the consensus problem called the stabilizing consensus problem [2]. In this problem, we do not require that each pro...
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ژورنال
عنوان ژورنال: Journal of Molecular Biology
سال: 2007
ISSN: 0022-2836
DOI: 10.1016/j.jmb.2006.11.044